期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 76, 期 11, 页码 4635-4644出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo2006335
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资金
- Ministerio de Ciencia y Tecnologia [CTQ2009-12168]
- UAM-Comunidad de Madrid
- Comunidad de Madrid [S-2009-PPQ-1634]
- DGAPA (UNAM)
The Friedel-Crafts reaction of methyl alkyl-and arylsulfinates with aromatic systems, activated by one or more electron-donating substituents (OH, OMe, NFIR, NR2), provides alkyl aryl and diaryl sulfoxides under mild conditions and in moderate to good yields. The very high regioselectivity usually observed in these sulfinylation reactions is rationalized on the basis of a Wheland intermediate having a trigonal bypyramidal structure in which steric and electronic interactions are significant factors strongly destabilizing the attack to the ortho positions.
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