期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 76, 期 24, 页码 10154-10162出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo201994v
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资金
- CSIR, New Delhi, India
An efficient synthesis toward highly diversified a-carboline derivatives via a three-component tandem reaction using acid chlorides, terminal allcynes, and 2-aminoindole hydrochlorides has been described. The salient feature of the one-pot strategy involves regioselective [3 + 3]-cyclocondensation and the presence of water in the reaction medium to facilitate cyclizafion. Nonaqueous conditions furnished products in poor yields.
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