期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 76, 期 21, 页码 9031-9045出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo201781x
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资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Merck and Merck Frosst Center for Therapeutic Research
- University of Toronto
- NSERC
- Deutsche Forschungsgemeinschaft (DFG)
An efficient and versatile synthesis of chiral tetralins has been developed using both inter- and intra-molecular Friedel Crafts alkylation as a key step. The readily available hydronaphthalene substrates were prepared via a highly enantioselective metal-catalyzed ring opening of meso-oxabicyclic alkenes followed by hydrogenation. A wide variety of complex tetracyclic compounds have been isolated with high levels of regio-, diastereo-, and enantioselectivity.
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