期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 76, 期 8, 页码 2594-2602出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo102471r
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资金
- Sanofi-Aventis
SSR 241586 is a 2,2-disubstituted morpholine, developed by Sanofi-Aventis, which is active in the treatment of schizophrenia and irritable bowel syndrome (IBS). Different strategies have been studied to synthesize this molecule and among the strategies an organo-catalyzed Henry reaction, applied to an a.-keto ester, has produced SSR 241586 in excellent enantiomeric excess.
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