期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 76, 期 18, 页码 7551-7555出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo201123p
关键词
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资金
- National Basic Research Program of China [2009CB626604, 2010CB833203]
- NSFC [20972058, 21032005]
- Fundamental Research Funds for the Central Universities [Lzujbky-2010-112]
- MOE of P. R. China
A highly efficient asymmetric Michael addition of 1-acetylindolin-3-ones to alpha,beta-unsaturated aldehydes is developed to afford 2-substituted indolin-3-one derivatives in high yields (up to 94%) with good stereoselectivities (up to 11:1 dr and 96% ee). The Michael adducts can be transformed into substituted cyclopentyl[b]indoline compounds conveniently without racemization.
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