期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 76, 期 16, 页码 6503-6517出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo200838v
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资金
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [809261] Funding Source: National Science Foundation
A thiourea/proline derivative-catalyzed synthesis of linear a-substituted tetrahydrofuran/pyran derivatives starting with lactol substrates is presented. This study demonstrates the utility and potential complications of using (thio)urea/proline cocatalysis as each of these catalysts is necessary to provide the observed reactivity, but a time-dependent decrease in enantioselectivity is observed. New mechanistic insights into (thio)urea/proline cocatalysis are presented.
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