期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 75, 期 14, 页码 4872-4875出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo100769n
关键词
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资金
- National Natural Science Foundation of China [20802074]
- National Basic Research Program of China (973 Program) [2010CB833300]
A bifunctional thiourea-tertiary amine-catalyzed asymmetric hydroxymethylation of 3-substituted oxindoles using paraformaldehyde as the C1 unit was developed. A wide scope of oxindoles, bearing C3 sterically congested quaternary carbon centers, were smoothly obtained in good to excellent yields (up to 99%) and high enantioselectivities (up to 91% ee) under mild reaction conditions. A more significant feature of this approach employs cheap and readily available paraformaldehyde as a hydroxymethylation Cl unit, which is activated by chiral bifunctional thiourea organocatalysts.
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