期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 75, 期 21, 页码 7099-7106出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo1011762
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资金
- Indena S.p.A.
A very efficient three-component synthesis of a series of syn alpha-hydroxy-beta-amino esters, obtained in high diastereoselection and yield, was realized starting from an aldehyde, benzylamine, and the ketene silyl acetals derived from Ley's lactones. The synthetic protocol was optimized and the above compounds were obtained without the isolation of intermediates. The origin of the observed diastereoselection was investigated through a computational model of the key reaction step.
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