4.7 Article

Asymmetric Mannich Reaction of Malonates with Imines Catalyzed by a Chiral Calcium Complex

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JOURNAL OF ORGANIC CHEMISTRY
卷 75, 期 3, 页码 963-965

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AMER CHEMICAL SOC
DOI: 10.1021/jo902383b

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  1. Japan Society for the Promotion of Science (JSPS)
  2. Global COE Program
  3. University of Tokyo, MEXT, Japan

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A chiral calcium complex was found to be effective for the Mannich reactions of malonates with N-Boc imines. The desired adducts were obtained in excellent yields (up to 95%) with moderate to good enantioselectivities (up to 77% ee).

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