期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 75, 期 10, 页码 3203-3207出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo9024732
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资金
- Agence Nationale de la Recherche [ANR-06-BLAN-0291-01]
- Agence Nationale de la Recherche (ANR) [ANR-06-BLAN-0291] Funding Source: Agence Nationale de la Recherche (ANR)
Fosmidomycin and its analogue FR-900098 are potent inhibitors of 1-deoxy-D-xylulose 5-phosphate reducto-isomerase (DXR), the second enzyme of the MEP pathway for the biosynthesis of isoprenoids. This paper describes the synthesis of analogues of the two reverse phosphonohydroxamic acids 3 and 4, in which the length of the carbon spacer is modified, the N-methyl group of 3 is replaced by an ethyl group, and the phosphate group is replaced by potential isosteric moieties, i.e., sulfonate or carboxylate functionalities. The potential of the synthesized analogues to inhibit the E. coli DXR was evaluated.
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