Glucose as a Clean and Renewable Reductant in the Pd-Nanoparticle-Catalyzed Reductive Homocoupling of Bromo- and Chloroarenes in Water

An efficient and highly sustainable Ullmann-type homocoupling of bromo- and chloroarenes, including the more challenging electron-rich chloroarenes (e.g., 4-chloroanisole). catalyzed by in situ generated Pd colloids, is carried Out in aqueous medium under relatively mild conditions (temperatures ranging from 40 to 90 degrees C). Glucose is used as a clean and renewable reductant. while tetra butylammonium hydroxide (TBAOH) acts as base, surfactant, and phase-transfer agent, creating a favorable environment for the catalyst. Pd nanoparticle sizes, morphology, and chemical composition are ascertained by TEM and XPS analyses.