期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 75, 期 24, 页码 8716-8719出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo101935k
关键词
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资金
- National Natural Science Foundation of China [20902083]
- Natural Science Foundation of Zhejiang Province, China [Y4090082]
The asymmetric domino Michael-S(N)2 reaction of various 1,3-dicarbonyl compounds to alpha-bromonitroalkenes is described for the first time, employing readily available cinchona-derived bifunctional thioureas as organocatalysts. The novel transformations were highly regio-, chemo-, diastereo-, and enantioselective, which simultaneously gave the chiral tricyclic 2,3-dihydrofurans, bicyclic 2,3-dihydrofurans, and tetrasubstituted 2,3-dihydrofurans with two vicinal chiral carbon centers.
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