4.7 Article

4-Bis(methylthio)methylene-2-phenyloxazol-5-one: Versatile Template for Synthesis of 2-Phenyl-4,5-functionalized Oxazoles

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JOURNAL OF ORGANIC CHEMISTRY
卷 75, 期 15, 页码 5195-5202

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AMER CHEMICAL SOC
DOI: 10.1021/jo100941f

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  1. CSIR, New Delhi
  2. DST

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4-Bis(methylthio)methylene-2-phenyloxazol-5-one has been shown to be a versatile template for the synthesis of various 2-phenyl-3,4-substituted oxazoles via nucleophilic ring-opening of oxazolone with various oxygen, nitrogen, and carbon nucleophiles and subsequent 5-endo cyclization of the resulting acyclic adducts in the presence of silver carbonate.

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