期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 75, 期 23, 页码 8319-8321出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo101849b
关键词
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资金
- National Natural Science Foundation of China [20802076, 20873145, 20972156]
- Chinese Academy of Sciences [DICP-S200802]
- Planned Science and Technology Project of Dalian [2009E11SF132]
A series of chiral 3-aryl-4-phosphonobutyric acid esters were synthesized in high enantioselectivities (93-98% ee) via the Rh-catalyzed asymmetric hydrogenation of the corresponding 3-aryl-4-phosphonobutenoates using a P-stereogenic BoPhoz-type phosphine-aminophosphine ligand. The methodology has been successfully applied to the asymmetric synthesis of a potential GABA(B) antagonist, (R)-phaclofen, in high enantioselectivity.
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