期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 75, 期 21, 页码 7052-7060出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo101598y
关键词
-
资金
- National Cancer Institute of the United States National Institutes of Health [CA-76497]
A total synthesis of (-)-callipeltosicle A (1) has been achieved. The core macrocycle was made via a dual macrolactonization/pyran hemiketal formation reaction, developed to circumvent issues related to the reversible nature of acylketene formation from beta-keto lactone substrates. Initial approaches to the core of the natural product that revolved around ring-closing metathesis (RCM) and relay ring-closing metathesis (RRCM) reactions are also described.
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