期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 75, 期 10, 页码 3461-3464出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo1003295
关键词
-
资金
- Council for Chemical Sciences of The Netherlands Organization for Scientific Research (NWO-CW)
A versatile synthesis of enantiomerically pure cis- and trans-2,5-disubstituted morpholines is described. Hydroxynitrile lyase-mediated cyanide addition onto aldehydes provided cyanohydrins in virtually quantitative yield and excellent enantioselectivity. Subsequent formation of diastereomerically pure amino esters via a three-step, one-pot reduction-transimination-reduction sequence followed by reduction and simultaneous protection provided cyclization precursors. Finally, cyclization and SmI2-mediated reductive detosylation completed the synthesis of cis- and trans-2,5-disubstituted morpholines in good yields and excellent diastereoselectivities.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据