期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 75, 期 7, 页码 2302-2308出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo100111t
关键词
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资金
- Centre for Chemical Genetics [LC06077]
- Gilead Sciences, Inc. (Foster City, CA, U.S.A.)
Intramolecular C-H arylations were employed as a key step in the synthesis of hitherto unknown fused purine systems: 13-substituted purino[8,9-f]phenanthridines and 11-substituted 5,6-dihydropurino[8,9-a]isoquinolines. The purino[8,9-f]phenanthridines were prepared in moderate yields by double C-H arylations of 9-phenylpurines with 1,2-diiodobenzene or, more efficiently, by consecutive Suzuki coupling of 9-(2-bromophenyl)purines with 2-bromophenylboronic acid followed by intramolecular C-H arylation. 5,6-Dihydropurino[8,9-a]isoquinolines were prepared in quantitative yields by intramolecular C-H arylations of 9-(2-chlorophenethyl)purines.
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