期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 74, 期 20, 页码 7603-7607出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo901064n
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资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan
Enantioselective copper-catalyzed ring-opening reactions of racemic ethynyl epoxides with amines using (R)-DTBM-MeO-BIPHEP as a chiral ligand have been found to give the corresponding amino alcohols in high yields with up to 94% ee. The reaction is considered to proceed via copper-allenylidene complexes as key intermediates. This methodology may provide a novel synthetic approach to optically active amino alcohols, the structures of which are widely found in many natural products, biologically active compounds, and chiral ligands.
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