期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 74, 期 7, 页码 2780-2787出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo900073z
关键词
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资金
- National Natural Science Foundation of China [20621063, 20532050]
- Chinese Academy of Sciences
The enantioselective hydrogenation of 2-benzylquinolines and 2-functionalized and 2,3-disubstituted quinolines was developed by using the [Ir(COD)Cl]2/bisphosphine/I-2 system with up to 96% ee. Moreover, mechanistic studies revealed the hydrogenation mechanism of quinoline involves a 1,4-hydride addition, isomerization, and 1,2-hydride addition, and the catalytic active species may be a Ir(III) complex with chloride and iodide.
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