4.7 Article

Mild Room-Temperature Palladium-Catalyzed C3-Arylation of 2(1H)-Pyrazinones via a Desulfitative Kumada-Type Cross-Coupling Reaction

期刊

JOURNAL OF ORGANIC CHEMISTRY
卷 74, 期 17, 页码 6870-6873

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AMER CHEMICAL SOC
DOI: 10.1021/jo901327y

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资金

  1. FWO (Fund for Scientific Research - Flanders (Belgium)
  2. Katholieke Universiteit Leuven
  3. IRO (Interfacultaire Raad voor Ontwikkelingssamenwerking)

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An efficient desulfitative Kumada-type cross-coupling protocol is reported for the C3-arylation of 5-chloro-3-(phenylsulfanyl)pyrazin-2(1H)-ones. The method has also been successfully extended to the arylation of some (hetero)aryl thioethers and thioesters.

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