期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 74, 期 20, 页码 7798-7803出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo9015166
关键词
-
资金
- Royal Institute of Technology
- Swedish Research Council
- Knut and Alice Wallenberg foundation
An easy and straightforward synthesis of alpha-amino amides via a base-mediated rearrangement of modified Weinreb amides into N,O-acetals is presented. Subsequent arylation, alkylation, alkenylation, or alkynylation of this intermediate affords the corresponding alpha-amino amides in excellent yields. Furthermore, a more generalized protocol for the alpha-arylation of Weinreb amides lacking an alpha-amino moiety is also discussed.
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