4.7 Article

Total Synthesis of Pteridic Acids A and B

期刊

JOURNAL OF ORGANIC CHEMISTRY
卷 74, 期 15, 页码 5584-5589

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AMER CHEMICAL SOC
DOI: 10.1021/jo9010365

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资金

  1. FAEP-UNICAMP
  2. FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo)
  3. CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
  4. INCT-INOFAR Proc. CNPq [573.564/2008-6]

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The total synthesis of pteridic acids A and B is reported. The convergent asymmetric synthesis involved the use of a diastereoselective ethyl ketone aldol reaction followed by an efficient spiroketalization and provided pteridic acids A and B in 2.9% and 2.8% overall yield, respectively.

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