期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 74, 期 16, 页码 6157-6162出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo9010443
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资金
- Christian Doppler Society
- Brazilian science foundations
- CNPq
- FAPERJ
- FINEP
The lipase-catalyzed kinetic resolution of rac-1-phenylethanol with vinyl acetate as acyl donor and cyclohexane as solvent has been investigated applying both microwave dielectric heating and conventional thermal heating in order to probe the existence of nonthermal microwave effects. All transformations were conducted at 40 degrees C in a dedicated reactor setup that allowed accurate internal reaction temperature measurements with use of fiber-optic probes. Quartz reaction vessels that allow higher levels of microwave power to be administered to the reaction mixture were used for all experiments. For all five studied immobilized lipases, the observed reactivities and enantioselectivities in microwave and oil bath experiments were identical and thus not related to the presence of the microwave field, The effect of magnetic stirring proved critical as too rapid stirring in sonic instances destroyed the enzyme support structure and led to altered reactivities and selectivities.
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