期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 74, 期 5, 页码 2246-2249出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo8027938
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资金
- Oregon State University (OSU) Venture Fund
A highly enantioselective and diastereoselective protocol for performing Mannich reactions has been developed by using a p-dodecylphenylsulfonamide-based proline catalyst. This catalyst facilitates the use of common, nonpolar solvents and increased concentrations as compared to alternative methods. A series of syn-selective Mannich reactions is reported, including the rapid access of alpha- and beta-amino acids surrogates. The use of the industrially attractive nonpolar solvents, such as 2-methyl-tetrahydrofuran, is also demonstrated.
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