期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 74, 期 17, 页码 6888-6890出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo900992w
关键词
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资金
- Instituto de Salud Carlos III [PI081234]
- Junta de Extremadura
- FEDER [PRI07A032, PRI08A039]
Herein we report a novel, diastereoselective, one-pot, two-step, Sequential synthesis of highly functionalized natural product-like spiropyrrolidinochromanones. The process consists of an Ugi four-component condensation of 3-formylchromones with amines, isocyanides, and glyoxylic acids followed by a nucleophilic conjugate addition and intramolecular cyclization. The experimental simplicity and tolerance to a wide variety of substituents makes this method suitable for combinatorial synthesis.
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