4.7 Article

One-Pot Synthesis of 2-Pyridones via Chemo- and Regioselective Tandem Blaise Reaction of Nitriles with Propiolates

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JOURNAL OF ORGANIC CHEMISTRY
卷 74, 期 19, 页码 7556-7558

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AMER CHEMICAL SOC
DOI: 10.1021/jo901642t

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资金

  1. Korea Research Foundation [KRF-2006-312C00587]
  2. Ministry of Education, Science and Technology [20090070898, 20090063004]
  3. National Research Foundation of Korea [과06A2601, 2009-0070898, 2006-312-C00587, 2008-0057805] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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The Blaise reaction intermediate, generated in situ from Reformatsky reagent and nitrile, reacted with propiolates in a chemo- and regioselective manner to afford 2-pyridone derivatives in good to excellent yields

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