期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 74, 期 3, 页码 1218-1222出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo802536q
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资金
- Universite Montpellier 2
- CNRS
- INSERM
Glyco oligonucleotide conjugates, each exhibiting two mannose and two galactose residues, were efficiently synthesized by two successive 1,3-dipolar cycloadditions (click chemistry). Two phosphoramidite derivatives were used: one bearing a bromoalkyl group as a precursor to azide functionalization and another bearing a propargyl group. After a first cycloaddition with a mannosyl-azide derivative, the bromine atoms were substituted with NaN3 and a second click reaction was performed with a 1'-O-propargyl galactose, affording the heteroglyco oligonucleotide conjugate.
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