期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 74, 期 10, 页码 3626-3631出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo900152n
关键词
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资金
- NIH
- Merck Research Laboratories
- Novartis
Parallel microscale experimentation was used to develop general conditions for the Suzuki-Miyaura cross-coupling of diversely functionalized primary alkyltrifluoroborates with a variety of aryl chlorides. These conditions were found to be amenable to coupling with aryl bromides, iodides, and triflates as well. The conditions that were previously identified through similar techniques to promote the cross-coupling of secondary alkyltrifluoroborates with aryl chlorides were not optimal for the primary alkyltrifluoroborates, thus demonstrating the value of parallel experimentation to develop novel, substrate specific results.
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