期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 73, 期 23, 页码 9292-9302出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo801850f
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资金
- CORPAQ (Quebec, Canada)
- Natural Sciences and Engineering Research Council of Canada (NSERC)
A short and efficient strategy for the first synthesis of Majoral-Type multivalent glycodendrimers bearing covalently bound alpha-D-mannopyranosides onto a cyclotriphosphazene scaffold assembled using single-step Step Sonogashira and click chemistry is reported. New glycoclusters with valencies ranging from 6 to 18 and different epitope spatial arrangements were obtained. Cross-linking abilities of this series of glycodendrimers were evaluated with the model lectin from Canavalia ensiformis (Concanavalin A). The decameric mannoside 23, built around 19, was shown to be much faster in cross-linking the tetravalent lectin Concanavalin A than the positive control, which is the polysaccharide mannan from yeast. The new glycoconjugates reported may be promising tools as probes or effectors of biological processes involving multivalent carbohydrate-binding proteins.
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