Understanding the behavior of N-tosyl and N-2-pyridylsulfonyl Imines in CuII-Catalyzed aza-friedel-crafts reactions

[GRAPHICS] The different behavior of N-tosyl imines and N-(2-pyridyl)sulfonyl imines in Cu-II-catalyzed AFCR is described. DFT theoretical calculations on the mode of coordination of the copper atom to both types of substrates allow understanding this different reactivity.