期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 73, 期 17, 页码 6497-6505出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo801108h
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-
资金
- EPSRC [EP/C51890X/1]
A concise, linear synthesis of the Stemona alkaloid (+/-)-neostenine is reported. Key features include an organocopper-mediated bislactone C-2-desymmetrization for the stereoselective construction of the cyclohexane-lactone C,D-rings. The assembly of the fused pyrrolo[1,2-a]azepine core was achieved by application of a [5 + 2] maleimide photocycloaddition. A custom FEP flow reactor was used to Successfully overcome the scale limitations imposed by a classical immersion well batch reactor. The synthesis was completed in 14 steps from furan, in 9.5% overall yield, without the use of any protecting groups.
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