期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 73, 期 21, 页码 8236-8243出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo8013287
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-
资金
- Government of Ontario
A convenient method for the preparation of fluorous aryl stannanes was developed as a means of expanding the general utility of the fluorous labeling strategy (FLS). Following the synthesis of a novel fluorous distannane, a palladium-catalyzed cross-coupling reaction was used to prepare the target compounds from aryl halides. The scope of the reaction was investigated by preparing a small library of model Compounds where the reaction yields were similar to those reported for the analogous procedures employing hexamethyl- or hexabutyldistannanes. The utility of the reported methodology was demonstrated through the successful synthesis of fluorous precursors to two established molecular imaging and therapy agents (FIAU, IUdR). These were radiolabeled With iodine-125 and the desired products isolated in high yield and effective specific activity.
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