期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 73, 期 11, 页码 3985-3995出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo800094q
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Asymmetric reduction of ketimines 1a-e with trichlorosilane can be catalyzed by the N-methylvaline-derived Lewis basic formamide anchored to a polymeric support (5a and 5b) with good enantioselectivity (<= 82% ee) and low catalyst loading (typically 15 mol %) at room temperature. This protocol represents a considerable simplification of the isolation procedure and is particularly suitable for a parallel synthesis of chiral amines 2a-e. The polymer-supported catalysts retain full activity after a multiple use.
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