期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 73, 期 12, 页码 4458-4463出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo800672b
关键词
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A short concise route to beta-aminophosphine boranes is presented via the desymmetrization of prochiral phosphine boranes, forming P-chirogenic aldehydes that are rapidly transformed to the target compounds employing reductive amination under microwave irradiation. This sequence provides a modular route to P-chirogenic P,N ligands, and in addition, the intermediate aldehydes are versatile P-chiral building blocks for ligand design in general. An alternative pathway via the corresponding alpha-carboxyphosphines is also described. The ligands were subsequently evalutated in the asymmetric conjugate addition of diethylzinc to trans-/beta-nitrostyrene.
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