期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 73, 期 9, 页码 3634-3637出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo8001408
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[GRAPHICS] A novel and convenient route to the asymmetric synthesis of 2,3-diamino acids via Mannich reaction of iminolactones 1a and 1b with N-protected imines has been achieved in good yields (up to 95%) and high diastereoselectivity (dr: > 99:1). Hydrolysis of the Mannich adducts under acidic conditions furnished the desired 3-aryl-2,3-diaminopropanoic acids in good yields (up to 85%) with excellent enantiomeric excesses (99% ee).
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