期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 73, 期 18, 页码 7102-7107出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo801279r
关键词
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资金
- National Institutes of Health [GM46059]
- MIT-Singapore Alliance
- American Chemical Society Organic Division
- Novartis
A method for the Pd-catalyzed carbonylation of aryl bromides has been developed using Xantphos as the ligand. This method is effective for the direct synthesis of Weinreb amides, 1 degrees and 2 degrees benzamides, and methyl esters from the corresponding aryl bromides at atmospheric pressure. In addition, a putative catalytic intermediate, (Xanphos)Pd(Br)benzoyl, was prepared and an X-ray crystal structure was obtained revealing an unusual cis-coordination mode of Xantphos in this palladium-acyl complex.
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