期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 73, 期 18, 页码 7181-7188出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo800971s
关键词
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资金
- Swedish Research Council
- Science Foundation Ireland
NIS/AgOTf-promoted glycosylations with ethyl 2,3-N,O-carbonyl-2-deoxy-1-thio-beta-D-glueopyranoside donors can be performed with either alpha- or beta-selectivity by tuning the reaction conditions. Small amounts of AgOTf (0.1 equiv) and short reaction times give beta-selectivity, whereas 0.4 equiv of AgOTf and prolonged reaction times afford alpha-linked products. NMR-monitored glycosylation and anomerization experiments show initial formation of exclusively the beta-linkage, which anomerizes, through an intramolecular mechanism involving an endocyclic C - O bond cleavage, to the alpha-linkage.
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