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Significance of myofibroblasts in oral squamous cell carcinoma

期刊

JOURNAL OF ORAL PATHOLOGY & MEDICINE
卷 40, 期 3, 页码 201-207

出版社

WILEY
DOI: 10.1111/j.1600-0714.2010.00999.x

关键词

leukoplakia; oral cancer

资金

  1. Danish Council for Independent Research Medical Sciences
  2. 'Direktor Emil Hertz og hustru Inger Hertz' Fond' (Copenhagen, Denmark)
  3. 'Fredheim Stiftung' (Vaduz, Lichtenstein)

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It is now recognized that the tumor microenvironment makes significant contribution to tumor progression. Activated fibroblast endothelial cells, inflammatory cells, and various extra cellular matrix components are parts of this microenvironment. Most of the activated fibroblasts are alpha-smooth muscle actin-positive myofibroblast that often represent the majority of tumor stromal cells. Their production of growth factors chemokines and extracellular matrix facilitates tumor growth. Myofibroblast have been demonstrated in close to 50% of oral squamous cell carcinomas. In this review, we highlight the histological distribution of myofibroblast in oral squamous cell and the myofibroblast relation to tumor growth on prognosis.

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