期刊
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
卷 69, 期 6, 页码 1578-1586出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.joms.2010.07.062
关键词
-
资金
- Rural Development Administration, Republic of Korea [PJ007170201006]
Purpose: This study involves a comparison between the bone regeneration of nano-hydroxyapatite (nHA), as derived from eggshells either with or without silk fibroin scaffolds, and the unfilled control in the rabbit calvarial bony defect model. Materials and Methods: Sixteen 4-month-old New Zealand white rabbits, with a mean weight of 2.8 kg (range, 2.5-3.0 kg), were used in this experiment. After the formation of bilateral parietal bony defects (diameter, 8.0 mm), either an nHA or an nHA + silk fibroin combination (nHA + silk) was grafted. The control was unfilled defect. The bone regeneration was evaluated by micro-computed tomography (mu CT) and histomorphometric analyses at 4 and 8 weeks. Results: All measured variables of the mu CT analysis were significantly higher in the grafted groups (nHA and nHA + silk) than in the unfilled control groups at both 4 and 8 weeks after operation (P < .05). On histomorphometric analysis, there was no significant difference between the groups at 4 weeks after operation. However, the nHA group exerted significantly higher bone regeneration (40.16% +/- 8.27%) compared with the unfilled control group (25.66% +/- 10.98%) or the nHA + silk group (16.62% +/- 3.05%) (P < .05). Conclusion: The nHA from eggshells exerted better bone formation than the unfilled control group on both mu CT and histomorphometric analyses. Considering the rapid healing in bony defect and easy availability, the nHA from the eggshells could prove to be a good new bone substitute. (C) 2011 American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 69:1578-1586, 2011
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