期刊
PHYSICAL MEDICINE AND REHABILITATION CLINICS OF NORTH AMERICA
卷 26, 期 1, 页码 57-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.pmr.2014.09.005
关键词
Cerebral palsy; Skeletal muscle; Extracellular matrix; Sarcomere; Fiber; Gene expression; Pathophysiology
资金
- National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health [AR057393, R24HD050837]
Patients with cerebral palsy present with a variety of adaptations to muscle structure and function. These pathophysiologic symptoms include functional deficits such as decreased force production and range of motion, in addition to changes in muscle structure such as decreased muscle belly size, increased sarcomere length, and altered extracellular matrix structure and composition. On a cellular level, patients with cerebral palsy have fewer muscle stem cells, termed satellite cells, and altered gene expression. Understanding the nature of these changes may present opportunities for the development of new muscle treatment therapies.
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