期刊
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
卷 53, 期 8, 页码 850-855出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JOM.0b013e31822589a9
关键词
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资金
- NIEHS [R01- ES005257, R01- ES007821, 000002, T32-ES07069, T32-HL007374]
- NIH [SBIR 2R44 ES03918-02]
- US Department of Veterans Affairs
Objective: Bone lead is a cumulative measure of lead exposure that can also be remobilized. We examined repeated measures of bone lead over 11 years to characterize long-term changes and identify predictors of tibia and patella lead stores in an elderly male population. Methods: Lead was measured every 3 to 5 years by k-x-ray fluorescence and mixed-effect models with random effects were used to evaluate change over time. Results: A total of 554 participants provided up to four bone lead measurements. Final models predicted a -1.4% annual decline (95% CI: -2.2 to -0.7) for tibia lead and piecewise linear model for patella with an initial decline of 5.1% per year (95% CI: -6.2 to -3.9) during the first 4.6 years but no significant change thereafter (-0.4% [95% CI: -2.4 to 1.7]). Conclusions: These results suggest that bone lead half-life may be longer than previously reported.
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