期刊
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
卷 40, 期 9, 页码 2015-2022出版社
WILEY
DOI: 10.1111/jog.12501
关键词
endometrial regeneration; endometriosis; side population; stem; progenitor cells
资金
- Japan Society for the Promotion of Science
- Keio University Sakaguchi-Memorial Medical Science Fund
- Japan Medical Association
- Uehara Memorial Foundation
Human endometrium regenerates and regresses with each menstrual cycle under hormonal control throughout a woman's reproductive life. The cyclical regeneration and remodeling potentials allude to the existence of stem/progenitor cells in the endometrium. There is increasing evidence that human endometrium contains small numbers of stem-like cells capable of self-renewal, multiple differentiation and tissue reconstitution. Although the precise identity of endometrial stem/progenitor cells remains elusive, these cells are thought to play pivotal role(s) in the physiological remodeling and regeneration of the human endometrium and also in the pathogenesis of endometrium-associated diseases, such as endometriosis.
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