4.2 Article

Extremely large nuchal translucency measurement predicts adverse pregnancy outcome

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JOURNAL OF OBSTETRICS AND GYNAECOLOGY
卷 35, 期 1, 页码 22-24

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INFORMA HEALTHCARE
DOI: 10.3109/01443615.2014.935713

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Down syndrome; 1st trimester; nuchal translucency; singleton pregnancy; ultrasound screening

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A prospective study was conducted to determine the outcome of pregnancies with 1st trimester nuchal translucency measurement of >= 6.5 mm. The risk of fetal abnormalities increases with enlarging nuchal translucency, being around 45% with a measurement of >= 6.5 mm. A total of 27,144 women with singleton pregnancies participated in the combined Down syndrome screening within the public healthcare system in Northern Finland. The study period was 1 May 2002 to 31 May 2009. The nuchal translucency measurement was >= 6.5 mm in 16 cases (0.06%). Pregnancy outcome was normal in one case (6.3%). The risk of abnormality was higher in our study than reported in the literature. According to our study, immediate diagnostic tests should be offered after an nuchal translucency measurement of >= 6.5 mm. We should also consider analysis of fetal micro-deletions associated with certain syndromes.

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