期刊
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
卷 57, 期 2, 页码 186-191出版社
CENTER ACADEMIC PUBL JAPAN
DOI: 10.3177/jnsv.57.186
关键词
Spirulina platensis; memory dysfunction; amyloid beta-protein; oxidative stress; antioxidant enzymes
资金
- National Science Council, Taiwan [NSC-95-231693-B-126-008]
- Taichung Veterans General Hospital and Providence University, Taichung, Taiwan [TCVGH-PU988104]
Spirulina has proven to be effective in treating certain cancers, hyperlipidemia, immunodeficiency, and inflammatory processes. In this study, we aimed to investigate the effects of Spirulina on memory dysfunction, oxidative stress damage and antioxidant enzyme activity. Three-month-old male senescence-accelerated prone-8 (SAMP8) mice were randomly assigned to either a control group or to one of two experimental groups (one receiving daily dietary supplementation with 50 mg/kg BW and one with 200 mg/kg BW of Spirulina platensis water extract). Senescence-accelerated-resistant (SAMR1) mice were used as the external control. Results showed that the Spirulina-treated groups had better passive and avoidance scores than the control group. The amyloid beta-protein (A beta) deposition was significantly reduced at the hippocampus and whole brain in both Spirulina groups. The levels of lipid peroxidation were significantly reduced at the hippocampus, striatum, and cortex in both Spirulina groups, while catalase activity was significantly higher only in the 200 mg/kg BW Spirulina group than in the control group. Glutathione peroxidase activity was significantly higher only in the cortex of the 200 mg/kg group than in that of the SAMP8 control group. However, superoxide dismutase activity in all parts of the brain did not significantly differ among all groups. In conclusion, Spirulina platensis may prevent the loss of memory possibly by lessening A beta protein accumulation, reducing oxidative damage and mainly augmenting the catalase activity.
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