期刊
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
卷 56, 期 1, 页码 54-59出版社
CENTER ACADEMIC PUBL JAPAN
DOI: 10.3177/jnsv.56.54
关键词
acidic xylooligosaccharides; prebiotics; atopic dermatitis; NC/Nga mouse; interleukin-12
We examined whether two types of xylooligosaccharides (neutral or acidic xylooligosaccharides) derived from hardwood kraft pulp ameliorate the development of atopic dermatitis (AD)-like skin lesions induced by repeated application of picryl chloride (PiCl) in NC/Nga mice. Oral administration of acidic xylooligosaccharides at a daily dose of 100 mg/kg significantly prevented the development of AD-like skin lesions. Serum histamine level was significantly suppressed, but serum total IgE level was not significantly suppressed. Moreover. the secretion of inflammatory cytokine IL-12 from splenic lymphocytes was significantly suppressed. On the other hand. neutral xylooligosaccharides showed no significant preventive effect on the development of AD-like symptoms. These results suggest that oral administration of acidic xylooligosaccharides may be effective in preventing the development of AD-like skin disease and one of the mechanisms is the suppressive effect on IL-12.
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