期刊
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
卷 56, 期 1, 页码 34-40出版社
CENTER ACADEMIC PUBL JAPAN
DOI: 10.3177/jnsv.56.34
关键词
atherosclerosis; hypercholesterolemia; rabbits; Spirulina platensis
资金
- Korean Government (MOEHRD)
- ES Biotech Co. (Cheonan, Korea)
- National Research Foundation of Korea [과09B2106] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The anti-atherogenic effects of spirulina (Spirulina platensis) were investigated in the New Zealand White (NZW) rabbit model. The animal had hypercholesterolemia induced by being fed a high cholesterol diet (HCD) containing 0.5% cholesterol for 4 wk. and then fed a HCD supplemented with 1 or 5%, spirulina (SP1 or SP5) for an additional 8 wk. Spirulina supplementation lowered intimal surface of the aorta by 32.2 to 48.31%, compared to HCD. Serum triglyceride (TG) and total cholesterol (TC) significantly were reduced in SP groups. After 8 wk, serum low density lipoprotein cholesterol (LDL-C) remarkably decreased by 26.4% in SP1 and 41.2% in SP5, compared to HCD. On the other hand, high density lipoprotein cholesterol (HDL-C) was markedly increased in SP1 and SP5 compared with that in the HCD group from 2 to 8 wk. These results suggest that spirulina intake can cause the reduction of hypercholesterolemic atherosclerosis, associated with a decrease in levels of serum TC, TG and LDL-C and an elevation of HDL-C level. Spirulina may. therefore. be beneficial in preventing atherosclerosis and reducing risk factors for cardiovascular diseases.
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