期刊
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
卷 25, 期 11, 页码 1101-1107出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2014.07.003
关键词
Anxiety; Dopamine; Iron deficiency; Iron overload; Norepinephrine; Oxidative stress; Serotonin
资金
- NIEHS [R00 ES017781, R01 ES014638]
- NIDDK [R01 DK064750]
Iron is required for appropriate behavioral organization. Iron deficiency results in poor brain myelination and impaired monoamine metabolism. Glutamate and gamma-aminobutyric acid homeostasis is modified by changes in brain iron status. Such changes produce not only deficits in memory/learning capacity and motor skills, but also emotional and psychological problems. An accumulating body of evidence indicates that both energy metabolism and neurotransmitter homeostasis influence emotional behavior, and both functions are influenced by brain iron status. Like other neurobehavioral aspects, the influence of iron metabolism on mechanisms of emotional behavior is multifactorial: brain region-specific control of behavior, regulation of neurotransmitters and associated proteins, temporal and regional differences in iron requirements, oxidative stress responses to excess iron, sex differences in metabolism, and interactions between iron and other metals. To better understand the role that brain iron plays in emotional behavior and mental health, this review discusses the pathologies associated with anxiety and other emotional disorders with respect to body iron status. (C) 2014 Elsevier Inc. All rights reserved.
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