期刊
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
卷 25, 期 12, 页码 1282-1295出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2014.07.004
关键词
Peach; NF kappa B-p65; RAGE; Antioxidant; Anti-inflammatory; Carbon tetrachloride
资金
- FAPERGS [PqG 12099/8, PRONEX 1000274]
- CAPES [PROCAD 066/2007]
- CNPq
- PROPESQ-UFRGS
- Embrapa
The present study was elaborated to comparatively evaluate the preventive effect of different peach-derived products obtained from preserved fruits (Syrup and Preserve Pulp Peach [PPP]) and from fresh peels and pulps (Peel and Fresh Pulp Peach [FPP]) in a model of liver/renal toxicity and inflammation induced by carbon tetrachloride (CCl4) in rats. Tissue damage (carbonyl, thiobarbituric acid reactive species and sulfhydril), antioxidant enzymes activity (catalase and superoxide dismutase) and inflammatory parameters [tumor necrosis factor (TNF)-alpha and interleukin (IL)-beta levels, and receptor for advanced glycation end-products (RAGE) and nuclear factor (NF)kappa B-p65 immunocontent] were investigated. Our findings demonstrated that Peel, PPP and FPP (200 or 400 mg/kg) daily administration by oral gavage for 30 days conferred a significant protection against CCl4-induced antioxidant enzymes activation and, most importantly, oxidative damage to lipids and proteins as well as blocked induction of inflammatory mediators such as TNF-alpha, IL-beta, RAGE and NF kappa B. This antioxidant/anti-inflammatory effect seems to be associated with the abundance of carotenoids and polyphenols present in peach-derived products, which are enriched in fresh-fruit-derived preparations (Peel and FPP) but are also present in PPP. The Syrup - which was the least enriched in antioxidants - displayed no protective effect in our experiments. These effects cumulated in decreased levels of transaminases and lactate dehydrogenase leakage into serum and maintenance of organ architecture. Therefore, the herein presented results show evidence that supplementation with peach products may be protective against organ damage caused by oxidative stress, being interesting candidates for production of antioxidant-enriched functional foods. (C) 2014 Elsevier Inc. All rights reserved.
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