期刊
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
卷 23, 期 8, 页码 853-859出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2012.03.003
关键词
Epigenetics; Nutri-epigenomics; One-carbon metabolism; Dietary methyl donors; DNA methylation
资金
- NIH [ES017524]
- University of Michigan NIEHS P30 Core Center [P30 ES017885]
- NIH/EPA [ES018171/RD 83480001]
- NIEHS [132 ES007062]
DNA methylation is the most extensively studied mechanism of epigenetic gene regulation. Increasing evidence indicates that DNA methylation is labile in response to nutritional and environmental influences. Alterations in DNA methylation profiles can lead to changes in gene expression, resulting in diverse phenotypes with the potential for increased disease risk. The primary methyl donor for DNA methylation is S-adenosylmethionine (SAM), a species generated in the cyclical cellular process called one-carbon metabolism. One-carbon metabolism is catalyzed by several enzymes in the presence of dietary micronutrients, including folate, choline, betaine and other B vitamins. For this reason, nutrition status, particularly micronutrient intake, has been a focal point when investigating epigenetic mechanisms. Although animal evidence linking nutrition and DNA methylation is fairly extensive, epidemiological evidence is less comprehensive. This review serves to integrate studies of the animal in vivo with human epidemiological data pertaining to nutritional regulation of DNA methylation and to further identify areas in which current knowledge is limited. (C) 2012 Elsevier Inc. All rights reserved.
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