期刊
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
卷 22, 期 3, 页码 289-292出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2010.02.007
关键词
Non-alcoholic fatty liver disease; Adipocyte-specific fatty acid-binding protein; Metabolic syndrome
资金
- Korean Association for the Study of the Liver Disease (KASLD)
- Korean Diabetes Association (KDA)
Adipocyte-specific fatty acid-binding protein (A-FABP) is a cytoplasmic protein that is expressed in adipocytes and is closely associated with insulin resistance, metabolic syndrome, and Type 2 diabetes. We investigated the relationship between A-FABP as a surrogate marker of metabolic syndrome and nonalcoholic fatty liver disease (NAFLD) in apparently healthy subjects. We assessed clinical and biochemical metabolic parameters and measured serum levels of A-FABP, high-sensitivity C-reactive protein and tumor necrosis factor-alpha (TNF-alpha) in 494 subjects who were divided into two groups according to the presence of NAFLD by abdominal ultrasonography. All parameters associated with metabolic syndrome were significantly higher in patients with NAFLD (P<.001). A-FABP showed positive correlation with TNF-alpha, homeostasis model assessment index of insulin resistance (HOMA-IR), and metabolic syndrome (P<.001) when adjusted for age and sex. The odds ratio for the risk of NAFLD in the highest teak of A-FABP compared with the lowest tertile was 7.36 (Cl 3.80-14.27, P<.001) after adjustment for age and sex; 4.52 (CI 2.22-9.20, P<.001) after adjustment for age, sex, HOMA-IR and metabolic syndrome and 2.86 (Cl 1.11-7.35, P<.05) after further adjustment for all metabolic parameters including TNF-alpha. The serum level of A-FABP was independently associated with NAFLD and showed significant correlation with TNF-alpha. HOMA-IR, and metabolic syndrome. (C) 2011 Elsevier Inc. All rights reserved.
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